Sexual Health · Compounded
Rated 4.85 by 134 RWell patients
TriMix Injections
TriMix is the gold-standard injectable for ED — direct, localized, and reliable. Effective even when oral medications haven't worked.
Starting at $158/mo
- Prescribed 100% online — no waiting rooms
- US-licensed clinicians
- Free 2-day shipping, discreetly packaged
- Transparent pricing with no hidden fees
Prescription products require an online consultation with a licensed clinician who will determine if a prescription is appropriate. Compounded medications are not FDA-approved or evaluated for safety, efficacy, or quality.
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How do TriMix injections work?
- TriMix is a compounded injectable that combines three vasoactive medications — typically alprostadil, papaverine, and phentolamine.
- Delivered as a small injection directly into the side of the penis, it relaxes smooth muscle and dramatically increases blood flow, producing a reliable erection within 5–20 minutes.
- Because it acts locally rather than through the bloodstream, TriMix works independently of arousal and is effective even when oral PDE5 inhibitors (like sildenafil or tadalafil) haven't worked — including for men with diabetes, vascular disease, or a history of prostatectomy.
Formulation
Trimix T-105: Papaverine 30mg / Phentolamine Mesylate 1mg / Prostaglandin E1 10mcg. Each 5 mL vial contains up to 10 doses at the maximum prescribed dose of 0.50 mL.
4 easy steps to get started
- 1
Complete a short online intake
Answer a secure health questionnaire about your history and goals — about 5–10 minutes.
- 2
A licensed clinician reviews your intake
A clinician licensed in your state reviews your answers, typically in under 4 hours.
- 3
Compounded by a licensed pharmacy
If appropriate, your compounded prescription is sent to our partner compounding pharmacy.
- 4
Shipped discreetly to your door
Your medication ships free with 2-day service in plain, unbranded packaging.
Results that speak for themselves
Why choose RWell?
Simple, transparent pricing
No membership fees. No hidden charges. Auto-refills – cancel at least 48-hours prior to next refill.
Every RWell Plan Includes:
- No cost consultation
- Free UPS 2nd Day Air
- No membership or hidden fees
- Unlimited messaging with your care team
LegitScript CertifiedMonthly – 5ml
$160
first month
Refills at $200
Auto-refills – cancel at least 48-hours prior to next refill
Quarterly – 15ml
Save 21%$158/mo
$475 total
Auto-refills – cancel at least 48-hours prior to next refill
Dosing and safety
TriMix is self-administered as a small injection 15–30 minutes before sexual activity. It should not be used more than once in a 24-hour period or more than three times per week. Your provider will start you on a conservative dose and gradually adjust it based on your response. We provide detailed injection instructions, ultra-fine needles, and all necessary supplies. Each 5 mL vial contains up to 10 doses at the maximum prescribed dose of 0.50 mL. Because treatment begins at a low dose and is gradually titrated, many patients will have medication remaining at the end of the month. To help maintain sterility, any unused medication should be discarded 28 days after the vial is first punctured, even if medication remains.
Possible side effects
- Mild pain or burning at the injection site
- Minor bruising
- Prolonged erection
- Penile fibrosis (with misuse/overuse)
The most serious risk is priapism — an erection lasting longer than 4 hours. This is a medical emergency that requires immediate care. Proper dosing and injection technique substantially reduce this risk. Do not use TriMix if you have sickle cell disease, severe cardiovascular disease, or a known penile deformity.
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Patient reviews
What patients say
4.8290 reviews
Reviews are unedited patient feedback. Star ratings are an aggregate of individual ratings across three categories: medical care and provider interactions, customer service and communication, and delivery experience. Shown with initials only for privacy. Individual results vary and are not guaranteed.
Frequently asked questions
TriMix is ideal for men who haven't had success with oral ED medications or who need a more reliable solution. It's particularly effective for men with diabetes, a history of prostate surgery, or other conditions affecting blood flow that limit the effectiveness of oral PDE5 inhibitors.
TriMix is considered the most effective ED treatment available, with success rates over 90%. Because it's injected directly, it works independently of arousal and provides very reliable results — even when oral medications have failed.
No. RWell providers don't prescribe phenylephrine injections, and we don't offer or advertise phenylephrine as part of our services.
Why not?
Because this treatment needs real-time monitoring. Phenylephrine is sometimes used off-label for priapism or prolonged erections, but clinical guidelines call for blood pressure and heart rate monitoring during and after each dose because of a real, if uncommon, risk of cardiovascular side effects.
That kind of monitoring belongs in a medical setting — not at home through telehealth.
Can I take Sudafed if an erection is lasting too long?
For some patients, yes. Pseudoephedrine HCl — the ingredient in original Sudafed — may be considered before an erection reaches the 4-hour mark, as long as you don't have contraindications.
Important: this does not mean Sudafed PE. Sudafed PE contains phenylephrine and is not the same medication.
Pseudoephedrine can raise blood pressure and heart rate, so patients with heart conditions, uncontrolled blood pressure, or other risk factors should ask a clinician before using it.
Learn more here: Penile Injection Instructions
What should I do if I have a prolonged erection?
Don't wait and hope it goes away.
If your erection is lasting longer than expected, follow the instructions provided with your medication and consider taking Sudafed well in advance of reaching the 4-hour mark, where this becomes an emergency. If you have an erection lasting 4 hours or more, seek emergency medical care right away or call 911.
No guessing. No toughing it out. Get checked.
Why does RWell take this approach?
Your safety comes first. RWell is built for convenient care, but not at the expense of clinical judgment. Some treatments just aren't appropriate for an at-home telehealth model, and our medical team has made the call not to offer phenylephrine injections for that reason.
Common side effects include mild pain or burning at the injection site, prolonged erection, and minor bruising. The most serious risk is priapism (an erection lasting more than 4 hours), which requires immediate medical attention. Proper dosing and technique minimize these risks.
Still have questions?
Get StartedWhen you need certainty.
Complete a quick health intake — your provider reviews within hours. Complete training, ultra-fine needles, and supplies included with every order.
Get StartedED Treatment is not offered in the following states: South Carolina.
Compounded medications are prepared by licensed compounding pharmacies and are not FDA-approved. The FDA does not evaluate compounded medications for safety, efficacy, or quality. Prescription products require an online consultation with a licensed clinician who will determine if a prescription is appropriate. Individual results vary. This page is for informational purposes only and is not medical advice.