RWellHome
    FDA-Approved · Daily ED Treatment
    Rated 5.0 by 96 RWell patients

    Daily Tadalafil

    Daily Tadalafil 5mg (Generic for Cialis®) stays in your system around the clock — no timing a pill, no awkward pauses. Clinically proven in 85%+ of men.

    Starting at $23/mo

    • Prescribed 100% online — no waiting rooms
    • US-licensed clinicians
    • Free 2-day shipping, discreetly packaged
    • Transparent pricing with no hidden fees

    Prescription products require an online consultation with a licensed clinician who will determine if a prescription is appropriate. Compounded medications are not FDA-approved or evaluated for safety, efficacy, or quality.

    Daily Tadalafil prescribed online by RWell
    Use your HSA/FSANo Hidden Fees24/7 MessagingFree Expedited ShippingNo Membership Fees
    Couple embracing after starting sexual health treatment

    How does Daily Tadalafil work?

    • Tadalafil blocks an enzyme called PDE5, which normally breaks down cGMP — the molecule responsible for relaxing blood vessels in the penis.
    • By blocking PDE5, tadalafil allows more blood to flow into the penis during arousal, producing a firmer erection that lasts long enough for satisfying sex.
    • With daily dosing, tadalafil reaches a steady state in your system within about 5 days.
    • Once at steady state, you don't need to time your dose around sexual activity — the medication is always working.

    Formulation

    A daily oral tablet that keeps you ready for spontaneous intimacy — with a 17.5-hour half-life, there's no rush.

    4 easy steps to get started

    1. 1

      Complete a short online intake

      Answer a secure health questionnaire about your history and goals — about 5–10 minutes.

    2. 2

      A licensed clinician reviews your intake

      A clinician licensed in your state reviews your answers, typically in under 4 hours.

    3. 3

      Compounded by a licensed pharmacy

      If appropriate, your compounded prescription is sent to our partner compounding pharmacy.

    4. 4

      Shipped discreetly to your door

      Your medication ships free with 2-day service in plain, unbranded packaging.

    Man completing his online telehealth visit at home

    Results that speak for themselves

    85%+

    Effective in clinical trials

    Daily tadalafil is effective in over 85% of men with erectile dysfunction.¹

    17.5hr

    Half-life

    The longest half-life of any PDE5 inhibitor — always ready when you are.⁵

    0

    Timing required

    No 30–60 minute wait. Daily dosing means the medication is always working.⁴

    Why choose RWell?

    Licensed Clinicians in 50 States + DC

    Every prescription is reviewed by a clinician licensed in your state, typically in under 4 hours.

    Compounded by licensed pharmacies

    Prepared by US-based compounding pharmacies to your prescribed strength.

    Discreet, expedited shipping

    Ships free with 2-day service in plain, unbranded packaging.

    Patient on a video call with a US-licensed RWell clinician

    Simple, transparent pricing

    No membership fees. No hidden charges. Auto-refills – cancel at least 48-hours prior to next refill.

    Every RWell Plan Includes:

    • No cost consultation
    • Free UPS 2nd Day Air
    • No membership or hidden fees
    • Unlimited messaging with your care team
    LegitScript Certified sealLegitScript Certified

    1 Year

    Save 25%

    $23/mo

    $270 total

    Auto-refills – cancel at least 48-hours prior to next refill

    Get Started

    90 Days

    $30/mo

    $90 total

    Auto-refills – cancel at least 48-hours prior to next refill

    Get Started
    Tadalafil 5mg Tablets:
    90 Days = 90 Tablets, 1 Year = 360 Tablets

    Dosing and safety

    Taken once daily at the same time, typically 2.5–5 mg. Your provider will determine the appropriate dose based on your health profile and response.

    Possible side effects

    • Mild headache
    • Heartburn
    • Back pain
    • Nasal congestion
    • Facial flushing

    Serious side effects are rare. Do not take tadalafil if you use nitrates (commonly prescribed for chest pain) — the combination can cause a dangerous drop in blood pressure. Not appropriate for individuals with a history of certain heart conditions or uncontrolled low blood pressure.

    Explore other sexual health treatments

    Ignite Melts
    In stock

    Sexual Health

    Ignite Melts

    Tadalafil 12mg + Sildenafil 60mg — Compounded Rapid Dissolving Tablet

    More confidence. More connection.

    Patient reviews

    What patients say

    4.8290 reviews
    • Respondwell has been great. They've also been really easy to work with – I needed to change my shipment schedule and they took care of it without any hassle.
      M.M. — verified patient
      5.0
    • Started seeing progress right away. Really happy with how things are going so far!
      J.C. — verified patient
      5.0
    • No complaints at all. Everything was explained clearly, the doctor was great, and my order showed up without any issues.
      D.K. — verified patient
      5.0
    • Very pleased so far. The whole experience has been easy and everything went exactly as expected.
      N.H. — verified patient
      5.0
    • Honestly, everything has been easy. Good communication, good experience with the doctor, and no issues getting my medication.
      A.Z. — verified patient
      5.0
    • Overall I've had a good experience. Shipping has been reliable and I've been very happy with everything.
      F.Y. — verified patient
      4.3

    Reviews are unedited patient feedback. Star ratings are an aggregate of individual ratings across three categories: medical care and provider interactions, customer service and communication, and delivery experience. Shown with initials only for privacy. Individual results vary and are not guaranteed.

    Frequently asked questions

    Daily tadalafil (the active ingredient in Cialis) is an FDA-approved erectile dysfunction treatment taken once daily at a low dose (2.5–5 mg). Unlike on-demand ED pills, it stays in your system continuously so you can get an erection whenever arousal occurs — no planning or timing required.

    Clinical trials show daily tadalafil is effective in over 85% of men with erectile dysfunction. Many men who didn't respond well to on-demand dosing see improved results with daily use due to consistent blood levels of the medication.

    With daily dosing, tadalafil reaches a steady state in your system within about 5 days. Once at steady state, you don't need to time your dose around sexual activity — the medication is always working. Initial effects can be noticed within 2 hours of the first dose.

    Daily tadalafil is ideal for men who want spontaneity without planning around a pill. Because it stays in your system continuously, there's no 30–60 minute wait before intimacy. On-demand dosing (10–20 mg) works well for less frequent sexual activity. Your provider will recommend the right approach based on your needs and health profile.

    Still have questions?

    Get Started

    Ready to feel confident again?

    Complete a quick health intake — your provider reviews within hours. No waiting rooms, no awkward conversations. Just effective treatment, delivered to your door.

    Get Started

    *Tadalafil is an FDA-approved medication for the treatment of erectile dysfunction. The information on this page is for educational purposes only and does not substitute for professional medical advice. Individual results may vary.

    Clinical References

    1 Porst, H., et al. (2006). Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction. European Urology, 50(2), 351–359.

    2 McMahon, C. (2004). Efficacy and safety of daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil. Journal of Sexual Medicine, 1(3), 292–300.

    3 Brock, G. B., et al. (2002). Efficacy and safety of tadalafil for the treatment of erectile dysfunction. Journal of Urology, 168(4), 1332–1336.

    4 U.S. Food and Drug Administration. (2018). Cialis (tadalafil) tablets: Full prescribing information (NDA 021368).

    5 Forgue, S. T., et al. (2006). Tadalafil pharmacokinetics in healthy subjects. British Journal of Clinical Pharmacology, 61(3), 280–288.

    ED Treatment is not offered in the following states: South Carolina.

    Compounded medications are prepared by licensed compounding pharmacies and are not FDA-approved. The FDA does not evaluate compounded medications for safety, efficacy, or quality. Prescription products require an online consultation with a licensed clinician who will determine if a prescription is appropriate. Individual results vary. This page is for informational purposes only and is not medical advice.