Compounded · GLP-1 Agonist
Rated 4.5 by 142 RWell patients
Semaglutide
Semaglutide — the most prescribed GLP-1 in the world — delivers up to 15% body weight loss, once a week.
Starting at $109/mo
- Prescribed 100% online — no waiting rooms
- US-licensed clinicians
- Free 2-day shipping, discreetly packaged
- Transparent pricing with no hidden fees
Prescription products require an online consultation with a licensed clinician who will determine if a prescription is appropriate. Compounded medications are not FDA-approved or evaluated for safety, efficacy, or quality.
Use your HSA/FSANo Hidden Fees24/7 MessagingFree Expedited ShippingNo Membership Fees
How does Semaglutide work?
- Semaglutide mimics GLP-1, a hormone released after eating.
- It signals fullness to your brain, slows stomach emptying, and helps regulate blood sugar — making it easier to eat less without feeling deprived.
Formulation
A once-weekly injection that reduces appetite and helps you feel fuller longer — backed by years of clinical data.
Enhanced with glycine
If indicated, your provider may prescribe a personalized formulation that includes glycine — a naturally occurring amino acid that supports collagen production, tissue repair, and muscle metabolism. Glycine has shown promise in preserving lean muscle during weight loss, reducing inflammation, and improving injection comfort.
4 easy steps to get started
- 1
Complete a short online intake
Answer a secure health questionnaire about your history and goals — about 5–10 minutes.
- 2
A licensed clinician reviews your intake
A clinician licensed in your state reviews your answers, typically in under 4 hours.
- 3
Compounded by a licensed pharmacy
If appropriate, your compounded prescription is sent to our partner compounding pharmacy.
- 4
Shipped discreetly to your door
Your medication ships free with 2-day service in plain, unbranded packaging.
Results that speak for themselves
Why choose RWell?
Simple, transparent pricing
No membership fees. No hidden charges. Auto-refills – cancel at least 48-hours prior to next refill.
Every RWell Plan Includes:
- No cost consultation
- Free UPS 2nd Day Air
- No membership or hidden fees
- Unlimited messaging with your care team
LegitScript Certified1 Month
$110
first order
Refills at $160
Auto-refills – cancel at least 48-hours prior to next refill
3 Months
Save 32%$109/mo
$329 total
Auto-refills – cancel at least 48-hours prior to next refill
🔥Starter Dose Launch Special: First order for only $110, future refills at regular price ($160)
Dosing and safety
Treatment begins at 0.25mg weekly and increases gradually over 4-5 months to the maintenance dose. This slow titration helps minimize side effects.
Possible side effects
- Nausea (improves over time)
- Decreased appetite
- Diarrhea or constipation
- Headache
Rare but serious risks have been reported, including pancreatitis, gallbladder problems, and kidney injury. GLP-1s may cause serious side effects, including possible thyroid tumors, including cancer. See the 'Important Safety Information' links below for more details.
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No constant cravings
Clothes that actually fit again
Real, visible results
Patient reviews
What patients say
4.8290 reviews
Reviews are unedited patient feedback. Star ratings are an aggregate of individual ratings across three categories: medical care and provider interactions, customer service and communication, and delivery experience. Shown with initials only for privacy. Individual results vary and are not guaranteed.
Frequently asked questions
Semaglutide is suited for adults seeking proven weight-loss results at a lower price point. It's generally recommended for people with a BMI over 27 (with weight-related conditions) or over 30, but not for those with certain thyroid cancers or severe gastrointestinal issues.
Clinical studies report average weight-loss of 14.9–17.4% over 68 weeks. Users often experience reduced appetite and fewer cravings early on, with consistent weight loss over several months. It's important to note that compounded medications should not be presumed equivalent to their branded counterparts, and they are not reviewed by the FDA for safety or effectiveness.
The most common side effects are GI-related – nausea, constipation, diarrhea, vomiting, and stomach discomfort – and they often improve over time. We start low and increase doses gradually to help minimize side effects. Rare but serious risks have been reported, including pancreatitis, gallbladder problems, and kidney injury. Tell your care team before surgery/anesthesia, since GLP-1s can slow gastric emptying.
Animal studies indicated a risk of thyroid C-cell tumors. The correlation to humans has not been established, but you should avoid GLP-1 medications if you or your family has a history of MTC or MEN2. Review Important Safety Information for full details.
No. We don't require insurance. You'll see clear pricing and can pay with HSA/FSA or credit/debit.
Still have questions?
Get StartedReady to try Semaglutide? (No lectures, we promise.)
If you've tried to lose weight before and it didn't work – we get it. That's exactly why we're here. Complete a quick eligibility check and a licensed provider will review your info.
Get Started*Compounded versions of semaglutide are not associated with Novo Nordisk and/or its genuine OZEMPIC® and/or WEGOVY® products. Compounded versions of semaglutide are not FDA approved, and neither the FDA nor any global regulatory agency has reviewed these products for safety, quality, or efficacy. GLP-1 medications may cause serious side effects, including possible thyroid tumors, including cancer. See the "Safety Information" links below for more details.
Clinical References
1 Wilding JPH, et al. STEP 1: Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002.
Compounded medications are prepared by licensed compounding pharmacies and are not FDA-approved. The FDA does not evaluate compounded medications for safety, efficacy, or quality. Prescription products require an online consultation with a licensed clinician who will determine if a prescription is appropriate. Individual results vary. This page is for informational purposes only and is not medical advice.